Sample size: 50ml | 10mg/ml | 500mg | 99% Purity
Formula: C14H12F6N2O – 4-((R)-2-((R)-2,2,2-trifluoro-1-hydroxyethyl)pyrrolidin-1-yl)-2-trifluoroMethyl)benzonitrile
Storage: at 20℃ 2 years
Half life: 24 hours
CAS No.: 1165910-22-4
Activity of LGD-4033:
LGD-4033 is a selective androgen receptor modulator a novel non-steroidal, oral SARM that binds to AR with high affinity (Ki of ~1 nM) and selectivity, class of androgen receptor (AR) ligands that is tissue selective, developed to treat muscle wasting associated with cancer, acute and chronic illness and age-related muscle loss. Expected to produce the therapeutic benefits of testosterone with improved safety, tolerability and patient acceptance due to tissue-selective mechanism of action and an oral route of administration. It demonstrates anabolic activity in muscles, anti-resorptive and anabolic activity in bones and a robust selectivity for muscle and bone versus prostate and sebaceous glands. LGD-4033 has recently completed a Phase I Multiple Ascending Dose study in healthy volunteers this randomized, double-blind, placebo-controlled Phase I study established the safety and tolerability up to doses of 22 mg.   
- ^ http://edrv.endojournals.org/cgi/content/meeting_abstract/32/03_MeetingAbstracts/P3-207
- ^ http://www.ligand.com/sarm
- ^ http://www.ligand.com/our-collaborations
- ^ H.Z. Ke, X.N. Wang, J. O’Malley, B. Lefker, D.D. Thompson (2005). “Selective androgen receptor modulators – Prospects for emerging therapy in osteoporosis?”. J Musculoskelet Neuronal Interact 5 (4): 355.
*This article is intended for educational / informational purposes only. THIS PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only.
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