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SR9009

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Description

Description

Sample size:  30ml  |  10mg/ml  |  300mg  |  99% Purity

M.Wt: 437.94
Formula: C20H24CIN3O4S – ethyl-3-(((4-chlorobenzyl)((5-nitrothiophen-2-yl)methyl)amino)methyl)pyrrolidine-1-carboxylate
Solubility: DMSO
Purity: >99%
Storage: at 20℃ 2 years
Half life: –
CAS No.: 1379686-30-2

 

Activity of SR-9009:

SR9009 is a research drug that was developed by Professor Thomas Burris of the Scripps Research Institute as an agonist of Rev-ErbA (i.e., increases the constitutive repression of genes regulated by Rev-ErbA)[1] with a half-maximum inhibitory concentration (IC50) = 670 nM for Rev-ErbAα and IC50 = 800 nM for Rev-ErbAβ.[2]

Activation of Rev-erb-α by in mice SR9009 increases exercise capacity in mice by increasing mitochondria in skeletal muscle.[3]

References

  1. ^ Dodson B (2013-08-20). “New drug mimics the beneficial effects of exercise”. Health and Wellbeing. Gizmag. Retrieved 2013-08-21.
  2. ^ Solt LA, Wang Y, Banerjee S, Hughes T, Kojetin DJ, Lundasen T, Shin Y, Liu J, Cameron MD, Noel R, Yoo SH, Takahashi JS, Butler AA, Kamenecka TM, Burris TP (May 2012). “Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists”. Nature 485 (7396): 62–8. doi:10.1038/nature11030. PMC 3343186. PMID 22460951. Lay summaryNature Magazine.
  3. ^ Woldt E, Sebti Y, Solt LA, Duhem C, Lancel S, Eeckhoute J, Hesselink MK, Paquet C, Delhaye S, Shin Y, Kamenecka TM, Schaart G, Lefebvre P, Nevière R, Burris TP, Schrauwen P, Staels B, Duez H (August 2013). “Rev-erb-α modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy”. Nat. Med. 19 (8): 1039–46. doi:10.1038/nm.3213. PMID 23852339. Lay summaryVoice of America (2013-07-19).

*This article is intended for educational / informational purposes only. THIS PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only.
 

For bulk purchases, please contact quant@researchsarms.co.uk

For Custom soloution orders, please contact custom@researchsarms.co.uk

Store at room temperature out of direct light.

This product is for research only and not for consumption.

1ML applicator is included with each order for your convenience but more can be added to your shopping cart.

Testing Documentation
Full Testing documentation will be uploaded to individual pages soon. To request it proir to this please email us at info@researchsarms.co.uk
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