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RAD140

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Description

Description

Sample size: 30ml  |  10mg/ml  |  10mg/ml   |   99% Purity

M.Wt: 393.83
Formula: C20H16CIN5O2 – 2-chloro-4-{[(1R,2S)-1-[5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl]-2-hydroxypropyl]amino}-3-methylbenzonitrile
Solubility: DMSO
Purity: >99%
Storage: at 20℃ 2 years
Half life: –
CAS No.: 1182367-47-0

 

Activity of RAD140:

RAD140 is an investigational selective androgen receptor modulator (SARM) for the treatment of conditions such as muscle wasting, currently under development by Radius Health, Inc. (RDUS).[1][2][3][4]

References

  1. ^ Jayaraman A, Christensen A, Moser VA, Vest RS, Miller CP, Hattersley G, Pike CJ (Apr 2014). “Selective androgen receptor modulator RAD140 is neuroprotective in cultured neurons and kainate-lesioned male rats”. Endocrinology 155(4): 1398–406. doi:10.1210/en.2013-1725. PMC 3959610. PMID 24428527.
  2. ^ Hamson DK, Wainwright SR, Taylor JR, Jones BA, Watson NV, Galea LA (Sep 2013). “Androgens increase survival of adult-born neurons in the dentate gyrus by an androgen receptor-dependent mechanism in male rats”. Endocrinology154 (9): 3294–304. doi:10.1210/en.2013-1129. PMID 23782943.
  3. ^ Miller CP, Shomali M, Lyttle CR, O’Dea LS, Herendeen H, Gallacher K, Paquin D, Compton DR, Sahoo B, Kerrigan SA, Burge MS, Nickels M, Green JL, Katzenellenbogen JA, Tchesnokov A, Hattersley G (Feb 2011). “Design, Synthesis, and Preclinical Characterization of the Selective Androgen Receptor Modulator (SARM) RAD140”. ACS Medicinal Chemistry Letters 2 (2): 124–9. doi:10.1021/ml1002508. PMC 4018048. PMID 24900290.
  4. ^ Chris Miller, Maysoun Shomali, C Richard Lyttle, Gary Hattersley (24 June 2012). “SUN-525: A Selective Androgen Receptor Modulator (RAD140) Induces Inflammation in Rat Right Heart Ventricle: Evidence for an Androgen-Specific, Species-Specific Mechanism”. The Endocrine Society’s 94th Annual Meeting and Expo, June 23–26, 2012 – Houston, TX. Endocrine Society. Retrieved 19 October 2015.

*This article is intended for educational / informational purposes only. THIS PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only.
 

For bulk purchases, please contact quant@researchsarms.co.uk

For Custom soloution orders, please contact custom@researchsarms.co.uk

Store at room temperature out of direct light.

This product is for research only and not for consumption.

1ML applicator is included with each order for your convenience but more can be added to your shopping cart.

Testing Documentation
Full Testing documentation will be uploaded to individual pages soon. To request it proir to this please email us at info@researchsarms.co.uk
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