Description
Sample size: 50ml | 10mg/ml | 500g | 99% Purity
M.Wt: 453.498
Formula: C21H18F3NO3S2
Solubility: Polyglycols
Purity: >99%
Storage: at 20℃ 2 years
Half life: 24 hours
CAS No.: 317318-70-0
Activity of GW-501516:
GW-501516 (also known as GW-501,516, GW1516) is an investigational PPARδ modulator compound.[1][2] It activates the same pathways activated through exercise, including PPARδ and AMP-activated protein kinase. It is being investigated as a potential treatment for obesity, diabetes, dyslipidemia and cardiovascular disease.[3][4]
GW-50156 regulates fat burning through a number of widespread mechanisms;[7] it increases glucose uptake in skeletal muscle tissue and increases muscle gene expression, especially genes involved in preferential lipid utilization.,[8][9][10] This shift changes the body’s metabolism to favor burning fat for energy instead of carbohydrates or muscle protein, potentially allowing clinical application for obese patients to lose fat effectively without experiencing muscle catabolism or the effects and satiety issues associated with low blood sugar.[11] GW-501516 also increases muscle mass, which improved glucose tolerance and reduced fat mass accumulation even in mice fed a very high fat diet, suggesting that GW-501516 may have a protective effect against obesity [12]
References
- ^ Sznaidman ML, Haffner CD, Maloney PR, Fivush A, Chao E, Goreham D, Sierra ML, LeGrumelec C, Xu HE, Montana VG, Lambert MH, Willson TM, Oliver WR Jr, Sternbach DD (May 2003). “Novel selective small molecule agonists for peroxisome proliferator-activated receptor delta (PPARdelta)–synthesis and biological activity”. Bioorg. Med. Chem. Lett. 13 (9): 1517–21. doi:10.1016/S0960-894X(03)00207-5. PMID 12699745.
- ^ Dimopoulos N, Watson M, Green C, Hundal HS (October 2007). “The PPARdelta agonist, GW501516, promotes fatty acid oxidation but has no direct effect on glucose utilisation or insulin sensitivity in rat L6 skeletal muscle cells”. FEBS Lett. 581 (24): 4743–8. doi:10.1016/j.febslet.2007.08.072. PMID 17869249.
- ^ Barish GD, Narkar VA, Evans RM (March 2006). “PPAR delta: a dagger in the heart of the metabolic syndrome”. J. Clin. Invest. 116 (3): 590–7. doi:10.1172/JCI27955. PMC 1386117.PMID 16511591.
- ^ Uwe Dressel, Tamara L. Allen, Jyotsna B. Pippal, Paul R. Rohde, Patrick Lau, and George E. O. Musc (2003). “The Peroxisome Proliferator-Activated Receptor β/δ Agonist, GW501516, Regulates the Expression of Genes Involved in Lipid Catabolism and Energy Uncoupling in Skeletal Muscle Cells”. Molecular Endocrinology (17): 2477–93. doi:10.1210/me.2003-015. PMID 14525954.
- ^ Narkar VA, Downes M, Yu RT, Embler E, Wang Y-X, Banayo E, Mihaylova MM, Nelson MC, Zou Y, Juguilon H, Kang H, Shaw RJ,2 Evans RM (August 2008). “AMPK and PPARδ Agonists Are Exercise Mimetics” (PDF). Cell 134 (3): 1–11. doi:10.1016/j.cell.2008.06.051. PMC 2706130. PMID 18674809.
- ^ “Exercise In A Pill: Researchers Identify Drugs That Enhance Exercise Endurance”. Science News. ScienceDaily. 2008-08-01. Retrieved 2008-08-01.
- ^ Normal 0 false false false EN-US X-NONE X-NONE http://www.sciencedirect.com/science/article/pii/S0092867403002691
- ^ Vihang A. Narkar, Michael Downes, Ruth T. Yu, Emi Embler, Yong-Xu Wang, Ester Banayo, Maria M. Mihaylova, Michael C. Nelson, Yuhua Zou, Henry Juguilon, Heonjoong Kang, Reuben J. Shaw, Ronald M. Evans, AMPK and PPARδ Agonists Are Exercise Mimetics, Cell, Volume 134, Issue 3, 8 August 2008, Pages 405-415, ISSN 0092-8674, 10.1016/j.cell.2008.06.051. (http://www.sciencedirect.com/science/article/pii/S0092867408008386)}}
- ^ Krämer DK, Al-Khalili L, Guigas B, Leng Y, Garcia-Roves PM, Krook A (July 2007). “Role of AMP kinase and PPARdelta in the regulation of lipid and glucose metabolism in human skeletal muscle”. J. Biol. Chem. 282 (27): 19313–20. doi:10.1074/jbc.M702329200. PMID 17500064.
- ^ Normal 0 false false false EN-US X-NONE X-NONE http://mend.endojournals.org/content/17/12/2477.short
- ^ http://mend.endojournals.org/content/17/12/2477.short
- ^ Normal 0 false false false EN-US X-NONE X-NONE http://www.plosbiology.org/article/info%3Adoi%2F10.1371%2Fjournal.pbio.0020294
*This article is intended for educational / informational purposes only. THIS PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only.
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